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TALEN™ Basic
Cell engineering tools for successful gene modifications
TALEN™ (Transcription Activator-Like Effector Nucleases) are a novel class of sequence-specific nucleases, created by fusing a transcription activator-like effector DNA binding domain to the catalytic head of an endonuclease. These nucleases allow DNA double strands breaks with very high efficiency and precision.
TALEN™ Basic is your Custom TALEN™ of choice for any gene modification projects. Tag genes, substitute nucleotides, swap promoters and more!
Available TALEN™ Basic validation levels
With TALEN™ Basic, choose from our available levels of validation of TALEN™ activity or request a custom validation.
Do not hesitate to contact us to discuss your cell engineering project and to define together the best TALEN™ and validation level answering your needs.
TALEN™ Basic validation level |
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No validation |
First human |
First mouse & rat |
Premium |
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| Cat. No | TALEN-BA-NV-RCT | TALEN-BA-FRH-RCT | TALEN-BA-FRMR-RCT | TALEN-BA-PRE-RCT |
| Description | Without any validation | Standard validation in human cell lines | Validation in mouse & rat cell lines | Validation in customers' cell lines |
|
Validation method |
- | Sequence specific mutagenesis activity on chromosomal target | ||
| - | Deep sequencing | |||
| Deliverables | 2 TALEN™ | 2 TALEN™ + validation report | Up to 3 TALEN™ + validation report | |
|
TALEN™ delivery timelines |
4 weeks | 4 weeks** | 9 weeks** | 12 weeks** |
* for immortalized cell lines
** additional 4 weeks for validation report
Related products and services
Specific solutions for methylated DNA
Are you aware of any limitations using TAL Effector nuclease in your cell lines such as high methylation levels?
At Cellectis bioreserarch we have the solution! Learn more about our TALEN™ CpG to edit methylated DNA.
Custom TALEN™ project support
For any of your gene editing projects, we offer Custom TALEN™ project support, a comprehensive service to learn how to optimize your TALEN™ project and how to use your TALEN™ in the most efficient way. Dedicated project support managers will share with you their expertise and know-how to define the best Custom TALEN™ suited for your sepcific gene editing project.
Cell Line Customization services
Do you have any other gene editing projects in mind? Would you like to take advantage of our expertise to design your Custom TALEN™ and engineer your cell line of choice directly?
Please visit our Cell Line Customization services page.