Rely on our R&D and bioinformatics expertise since 1999 for your best TALEN™ design

The Cellectis R&D team has been working in protein engineering with sequence-specific endonuleases, DNA repair mechanisms, and protein engineering since 1999.

We have used our years of experience to improve and optimize TALEN™ designs and create our Custom TALEN™ Services.

TALEN™ Hit Software

Genome coverage studies at Cellectis bioresearch using our exclusive TALEN™ Hit Software reveal a TALEN™ hit every two to three nucleotides. This provides significant advances in flexibility of design and application over other sequence-specific nuclease-based technologies, such as ZFNs, which can have limits in design and positioning relative to the desired mutation site. The estimated frequency of targetable sites for open source ZFNs is every several hundred base pairs (context-dependent assembly platform). Commercial sources of ZFNs offer targeting of the first two-thirds of the open reading frame, which does not guarantee sure gene knock-out and which may lead to partially functional proteins.

The generated hit search results do not give any indications on the best suited TALEN™ for your project but an overview of possible TALEN™ hits in your region of interest.

Amongst this large choice of TALEN™ hits, our bioinformatics experts will identify your Custom TALEN™ based on know-how and experience in gene customization.

TALEN projects

Examples of possible gene editing projects with TALEN™ such as gene-knock out and gene modification.

With Cellectis bioresearch Custom TALEN™ Services, all gene customization projects such as gene knock-out, gene tagging, promoter swapping and nucleotide substitution; or protein truncation, and all of your new project ideas, can be easily achieved.