Cardiomyocytes

Effective tools for in vitro evaluation of cardiotoxicity

hES-CMC™ are mixed populations of hES-derived cardiomyocytes (including support cells, e.g. fibroblasts). They represent a consistent and convenient source of large numbers of physiologically relevant cardiomyocytes and are excellent in vitro tools for studies of human cardiomyocyte function and for cardiac safety pharmacology assays.

hES-CMC™ are spontaneously beating human embryonic stem (hES) cell derived cardiomyocytes and exhibit specific markers and functional similarities to adult human cardiomyocytes. hES-CMC™ are available from the hESC line SA121, registered at the European hESC registry.

Reference Format Size No. of cells
CMC-201-VIAL-01 Frozen 1 vial suitable for one 96-well plate >3.0x106
CMC-202-CLUS Fresh 96-well plate with 1 cluster/well 20,000 cells/cluster

Benefits

  • Relevant & predictive toxicology data
    • human ES-derived cells with expression of main cardiotoxicity markers and functional similarities to adult human cardiomyocytes
  • Reproducibility
    • low lot-to-lot variation (<20%)
    • continuous supply of material from a consistent genetic background
  • Large scale screening campaigns
    • continuous supply of material from a consistent genetic background
  • Flexibility
    • fresh and frozen formats
    • clusters or single cell culture
  • Long-term toxicology studies
    • viable and functional cells up to 1 month
Applications: Typical assays:
  • Safety pharmacology
  • Cardiotoxicity testing
  • Discovery of novel cardiac drug targets
  • High Content Analysis
  • Micro Electrode Array (MEA)
  • Voltage-clamp studies
  • Transmembrane Action Potential (TAP)
  • hERG channel inhibition
  • Ion channel trafficking

 

 

Copyright 2012 Cellectis
Design & Development by EtonDigital