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Cell-based assays
A crucial issue in the phase of target identification is to establish reliable tools, such as stable and robust cell-based assays, to carry out the screening of chemicals or biological compounds with highest success to minimize the number of false positives and to maximize the number of confirmed hits.
Most cellular assays, based on transient expression system, show wide variability in gene expression, as a result of integration site and epigenetic regulation due to multi-copy integration and genomic instability. Furthermore, these methods are time consuming and expensive.
Using Cellectis bioresearch nuclease-driven targeted integration, stable and isogenic cell lines represent a good way to achieve consistent and reliable data.
Cellectis bioresearch has developed cGPS® Targeted Integration (TI) kits for the fast and effortless generation of stable and isogenic cell lines from engineered cell lines.
We also offer a Targeted Integration Service to generate stable and isogenic cell clones, or polyclonal population, expressing the customer's transgene of interest, by use of cGPS® TI kit.
