Targeted integration of shRNAs

Meganuclease-driven targeted integration can be used to generate stably silenced cell lines: any integrated shRNA will always be expressed from the same genomic position at the same level, bringing more robustness to the cellular assay.

A breakthrough in stable cell line generation!

cGPS^® targeted integration: easy and ready to use, saves time, effort and money.

The key benefits of meganuclease-driven targeted integration are:

cGPS^®: the cellular Genome Positioning System  revolution

cGPS^® products send your transgene to the desired destination in no time

Targeted integration corresponds to the stable genomic integration of a DNA sequence, most of the time a transgene expression cassette, at a unique genomic position. The unique genomic position has been selected to guarantee an adequate transcriptional activity.

We bring expert tools at your bench

Genome customization is our promise to bring to your bench easy and ready-to-use research tools to generate the cells and organisms with your desired characteristics.

The genome customization toolkit includes reagents and protocols enabling precise modifications of DNA sequences in a targeted genome, whether it is a cell line, a primary or stem cell, or even a whole organism.

Fast and effortless targeted integration kits

Together, Cellectis, with expertise in genome engineering, and Cellectis bioresearch, with experience and skills in product development, can supply today’s researchers with easy  and ready-to-use Targeted Integration kits for the generation of stable and isogenic cell lines. cGPS^® Targeted Integration kits can be purchased directly via our e-store or through our network of distributors.

Customize your genome with meganucleases

Cellectis bioresearch’s mission is to provide easy access to Meganucleases and their enabling potential to modify the DNA sequence of a target genome with high precision. Meganucleases are highly specific DNA endonucleases which provide the biotechnology industry with a full set of Genome Customization tools.