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Gene Function

Gene Function

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Fast and effortless generation of stable and isogenic clones for overexpression and silencing studies

Cellectis bioresearch has developed cGPS® Custom targeted integration kits  for the fast and effortless generation of stable and isogenic cell lines from native cell lines. You can now easily generate isogenic cell lines overexpressing gene variants and obtain robust functional data for comparison. Your silencing  studies can also take advantage of constitutive and targeted expression of shRNAs to easily obtain robust functional data.

Should you perform gene function studies in HEK-293, NIH-3T3 or CHO-K1 cell lines, make sure you have a look at our cGPS® targeted integration kits.

Benefit  from cGPS® and cGPS® Custom targeted integration using one of our Full Kits for gene function studies:

cGPS Custom HEK-293 Full Kit

cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines. Enables the effortless generation of stable HEK-293 isogenic clones in 26 days. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory\'s proprietary derived HEK-293 clones. Can be applied to any human derived cell line.

  • Selection of clones in 26 days
  • 85% of targeted integration events
  • Stable expression >10 weeks even in the absence of selection agents
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cGPS Custom Human Full Kit

cGPS® (cellular Genome Positioning System) Custom technology based on meganuclease-driven homologous recombination for targeted integration in native cell lines. Enables the fast and effortless generation of stable human-derived isogenic clones. Ideal for robust gene functional studies and data comparisons and for the generation of cell-based assays from laboratory\'s proprietary human-derived clones.

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cGPS HEK-293 Duo Full Kit

cGPS® (cellular Genome Positioning System) technology based on meganuclease-driven homologous recombination for targeted integration in engineered cell lines. Contains two gene integration sites by combining the advantages of the cGPS HEK-293 and cGPS Custom HEK-293 kits. Ideal to develop cell-based assays with difficult to express targets. The Duo product allows working with inducible expression system and expressing multimeric drug targets. 

  • 95% of targeted integration events 
  • stable expression >12 weeks even in the absence of selection agents
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